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Oct 28, - Some swear a supplement or two can get sexual desire sizzling again -- but what do the studies show Can Supplements Help Your Sex Life? Benefit #2: Enhances Libido. Vitamins B3, B6, and B12 are major factors in increasing libido. Vitamin B3 is in charge of anaerobic metabolism, which offers sexual energy and raises blood flow to the genitals. Vitamin B6 regulates prolactin that handles levels of sexual enjoyment in men.